Compounded Semaglutide information for prescribers

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• The majority of patients prefer a sublingual route of administration over injections.

Patient Safety

• Though there are pharmacies that can dependably compound sterile products, there are other sources on the internet without a previous reputation of quality and safety. One must choose carefully from many available sources.

• Was the Semaglutide used in the compounds sourced from an FDA-registered site? This can make a difference whether the powder is tested reliably for purity and potency.

Efficacy

• Is the compounding entity using the salt form known as Semaglutide sodium? Although there is some evidence to suggest that the base form and the salt form have similar activity, the FDA is not recommending the use of the sodium form as a substitute

• There has been an increase in calls to poison control regarding Semaglutide injections. This is likely due to multi dose vials being dispensed to patients, resulting in larger than intended doses being injected.

Efficacy

• The molecular weight of Semaglutide is very large at 4113 g/mol. It is very unlikely that a molecule of this size would readily penetrate the nasal mucosa to get into the blood stream

Efficacy

• The molecular weight of Semaglutide will be a problem for absorption in the sublingual cavity without an appropriate vehicle to assist in penetration.

Patient Safety

• Some products have been made using a powerful solvent, DMSO. This chemical is indiscriminate in what it will push through the mucosa, including substances unintended at the time of dosing. DMSO is not currently recommended for oral use.